diff --git a/scripts/startup/bl_operators/wm.py b/scripts/startup/bl_operators/wm.py
index ba52d48f547..36507370399 100644
--- a/scripts/startup/bl_operators/wm.py
+++ b/scripts/startup/bl_operators/wm.py
@@ -1672,7 +1672,8 @@ class WM_OT_properties_edit(Operator):
             self.soft_max_float = rna_data["soft_max"]
             self.precision = rna_data["precision"]
             self.step_float = rna_data["step"]
-            self.subtype = rna_data["subtype"]
+            if rna_data["subtype"] in self.subtype_items_cb(None):
+                self.subtype = rna_data["subtype"]
             self.use_soft_limits = (
                 self.min_float != self.soft_min_float or
                 self.max_float != self.soft_max_float
diff --git a/source/blender/editors/animation/anim_channels_edit.cc b/source/blender/editors/animation/anim_channels_edit.cc
index c7d0fff8072..54370669bab 100644
--- a/source/blender/editors/animation/anim_channels_edit.cc
+++ b/source/blender/editors/animation/anim_channels_edit.cc
@@ -2240,6 +2240,17 @@ static int animchannels_delete_exec(bContext *C, wmOperator * /*op*/)
         /* try to delete the layer's data and the layer itself */
         BKE_gpencil_layer_delete(gpd, gpl);
         ale->update = ANIM_UPDATE_DEPS;
+
+        /* Free Grease Pencil data block when last annotation layer is removed, see: #112683. */
+        if (gpd->flag & GP_DATA_ANNOTATIONS && gpd->layers.first == nullptr) {
+          BKE_gpencil_free_data(gpd, true);
+
+          Scene *scene = CTX_data_scene(C);
+          scene->gpd = nullptr;
+
+          Main *bmain = CTX_data_main(C);
+          BKE_id_free_us(bmain, gpd);
+        }
         break;
       }
       case ANIMTYPE_GREASE_PENCIL_LAYER: {
diff --git a/source/blender/editors/gpencil_legacy/gpencil_data.cc b/source/blender/editors/gpencil_legacy/gpencil_data.cc
index 974ba53d4ba..056b864dc7f 100644
--- a/source/blender/editors/gpencil_legacy/gpencil_data.cc
+++ b/source/blender/editors/gpencil_legacy/gpencil_data.cc
@@ -345,6 +345,17 @@ static int gpencil_layer_remove_exec(bContext *C, wmOperator *op)
   WM_event_add_notifier(C, NC_GPENCIL | ND_DATA | NA_EDITED, nullptr);
   WM_event_add_notifier(C, NC_GPENCIL | ND_DATA | NA_SELECTED, nullptr);
 
+  /* Free Grease Pencil data block when last annotation layer is removed, see: #112683. */
+  if (is_annotation && gpd->layers.first == nullptr) {
+    BKE_gpencil_free_data(gpd, true);
+
+    bGPdata **gpd_ptr = ED_annotation_data_get_pointers(C, nullptr);
+    *gpd_ptr = nullptr;
+
+    Main *bmain = CTX_data_main(C);
+    BKE_id_free_us(bmain, gpd);
+  }
+
   return OPERATOR_FINISHED;
 }